1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene

Base Information

• Chemical Name: 1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene
• CAS No.: 1032197-05-9
• Molecular Formula: C₁₁H₉Br
• Molecular Weight: 221.096
• Mol file: 1032197-05-9.mol

Synonyms:1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene

Chemical Property of 1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene

Chemical Property:

Purity/Quality:

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Technology Process of 1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene

There total 1 articles about 1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-Bromo-2-iodobenzene (583-55-1) + 2-methylbut-1-en-3-yne (78-80-8) → 1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene (1032197-05-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b03888

Reference yield:

Triisopropyl borate (5419-55-6) + 1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene (1032197-05-9) + water (7732-18-5) → (2-(3-methylbut-3-en-1-yn-1-yl)phenyl)boronic acid

Guidance literature:

1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 16h; Inert atmosphere;

water; With hydrogenchloride; In tetrahydrofuran; hexane; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03888

Reference yield:

1-bromo-2-(3-methylbut-3-en-1-yn-1-yl)benzene (1032197-05-9) → 2-[2-(2-bromophenyl)ethynyl]-2-methyloxirane (1032196-47-6)

Guidance literature:

With Na₂HPO₄; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1002/ejoc.200700963

upstream raw materials:

1-Bromo-2-iodobenzene

2-methylbut-1-en-3-yne

Downstream raw materials:

2-[2-(2-bromophenyl)ethynyl]-2-methyloxirane