78-80-8

Basic information

• Product Name: 2-Methyl-1 -butene-3-yne
• Synonyms: 2-Methyl-1-buten-3-yne;2-Methyl-1-butene-3-yne; 2-Methyl-1-butenyne; 2-Methylbutenyne;3-Methyl-3-buten-1-yne; 3-Methyl-3-butene-1-yne; Isopropenylacetylene; NSC9296; Valylene
• CAS NO: 78-80-8
• Molecular Formula: C₅H₆
• Molecular Weight: 66.11
• EINECS: 201-144-9
• Mol File: 78-80-8.mol
• Article Data: 26

Chemical Properties

• Melting Point: -113 °C
• Boiling Point: 32 °C(lit.)
• Flash Point: 20 °F
• Appearance: /
• Density: 0.695 g/mL at 25 °C(lit.)
• Vapor Pressure: 598mmHg at 25°C
• Refractive Index: 1.417
• CAS DataBase Reference: 2-Methyl-1 -butene-3-yne(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-1 -butene-3-yne(78-80-8)
• EPA Substance Registry System: 2-Methyl-1 -butene-3-yne(78-80-8)

Safety Data

• Hazardous Substances Data: 78-80-8(Hazardous Substances Data)

Usage

General Description

2-Methyl-1-butene-3-yne, also known as 3-ethyl-1-pentene, is an organic compound with the chemical formula C6H10. It is classified as an alkyne, as it contains a carbon-carbon triple bond. 2-Methyl-1 -butene-3-yne is a colorless, flammable gas at room temperature and pressure. It is commonly used as a reagent in organic synthesis and is often employed in the production of various pharmaceuticals and agrochemicals. 2-Methyl-1-butene-3-yne is also utilized in the manufacturing of plastics, rubber, and other industrial materials. Additionally, it is a valuable intermediate in the production of fine chemicals and is used in the synthesis of a range of organic compounds. Overall, 2-Methyl-1-butene-3-yne plays a significant role in the chemical industry as a versatile building block for the synthesis of a variety of important products.

InChI:InChI=1/C5H6/c1-4-5(2)3/h1H,2H2,3H3

Upstream product

• 64-18-6 formic acid 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 40459-85-6 α,α-dichloroethylcyclopropane 
• 21678-37-5 N,N,2-trimethylpropionamide 
• 26189-59-3 1-chloro-1-(dimethylamino)-2-methyl-1-propene 
• 335-03-5 1,1-difluoro-2,2-dimethylcyclopropane 
• 115-11-7 isobutene 
• 74-86-2 acetylene 
• 187737-37-7 propene 
• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 7732-18-5 water 
• 64-17-5 ethanol 
• 86119-84-8 phosphoric acid 
• 108-95-2 phenol 

Downstream Products

• 13152-69-7 4-methyl-1-(3-methyl-but-3-en-1-ynyl)-cyclohexanol 
• 19837-34-4 N,N,4-trimethylpent-4-en-2-yn-1-amine 
• 2696-26-6 2,5-dimethylhex-5-en-3-yn-2-ol 
• 3601-67-0 2,5-Dimethyl-5-hydroxy-hepten-1-in-3 
• 54340-94-2 4-butoxy-3-methyl-butan-2-one 
• 130423-06-2 (Z)-3-chloro-5-(o-chlorophenyl)-2-methyl-1,3-pentadien-5-one 
• 130444-18-7 4-chloro-6-(o-chlorophenyl)-3-methyl-2H-pyran 
• 91891-84-8 2-methyl-3-(phenylthio)-1,3-butadiene 
• 948-33-4 1,2,4-tris(prop-1-en-2-yl)benzene 
• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 29871-32-7 2,3-Dichloro-3-methyl-1-butene 
• 1809-02-5 2-chloro-3-methylbutadiene 
• 76397-24-5 4-chloro-3-methyl-1,2-butadiene 
• 52842-49-6 (E)-1,3-dichloro-2-methyl-2-butene 

Relevant articles and documents

CATALYZED HYDROSILYLATION OF 2-METHYL-1-BUTEN-3-YNE WITH METHYLDICHLOROSILANE; PROMOTIONAL EFFECT IMPARTED BY THE PRESENCE OF A DIFFERENT CHLOROSILANE

Chloroplatinic acid catalyzed hydrosilylation of 2-Methyl-1-buten-3-yne with chlorosilanes is reinvestigated; the results can't be satisfactorily explained by Chalk and Harrod mechanism.

Total Synthesis and Biological Investigation of (?)-Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific

Here, we describe an efficient and diversity-oriented entry to both (?)-artemisinin (1) and its natural antipode (+)-artemisinin, starting from commercially and readily available S-(+)- and R-(?)-citronellene, respectively. Subsequently, we answered the still open question regarding the specificity of artemisinins action. By using a drug-sensitive Plasmodium falciparum NF54 strain, we showed that the antimalarial activity of artemisinin is not stereospecific. Our straightforward and biomimetic approach to this natural endoperoxide enables the synthesis of artemisinin derivatives that are not accessible through applying current methods and may help to address the problem of emerging resistance of Plasmodium falciparum towards artemisinin.

Aluminum oxide-induced gas-phase ring-opening in methyl substituted gem-difluorocyclopropanes, leading to 2-fluorobuta-1,3-dienes and vinylacetylenes

A gas-phase pyrolysis of methyl-substituted gem-difluorocyclopropanes in a flow-tube reactor in the presence of Al2O3 at 185 - 250 °C gives 2-fluorobuta-1,3-dienes and vinylacetylenes.