N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Base Information

Chemical Name:N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide
CAS No.:1450833-06-3
Molecular Formula:C₃₁H₃₈N₂O₅
Molecular Weight:518.653
Hs Code.:

Synonyms:N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Suppliers and Price of N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

There total 11 articles about N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1450834-05-5
C₅₉H₆₂N₂O₅

: 1450833-06-3
N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Guidance literature:: With hydrogenchloride; palladium on carbon; hydrogen; In methanol; water; at 20 ℃;
DOI:10.1016/j.bmc.2013.06.054

Reference yield:

: 537030-19-6
(2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide

: 1450833-06-3
N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: tetrahydrofuran / 15 h / 0 °C / Inert atmosphere

2.1: zinc; acetic acid / 8 h / 20 °C

3.1: triethylamine / dichloromethane

4.1: ozone

5.1: sodium tetrahydroborate

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

6.2: 20 °C

7.1: hydrogenchloride / methanol; water / 0.5 h / 100 °C

8.1: triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C

9.1: hydrazine hydrate / ethanol / 3 h / Reflux

10.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 5 h / 20 °C

11.1: palladium on carbon; hydrogenchloride; hydrogen / methanol; water / 20 °C

With hydrogenchloride; sodium tetrahydroborate; palladium on carbon; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ozone; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.06.054

Reference yield:

: (2R,3R,4R,5R)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-5-vinylpyrrolidine

: 1450833-06-3
N-(4-((2R,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl) pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane

2.1: ozone

3.1: sodium tetrahydroborate

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 20 °C

5.1: hydrogenchloride / methanol; water / 0.5 h / 100 °C

6.1: triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C

7.1: hydrazine hydrate / ethanol / 3 h / Reflux

8.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 5 h / 20 °C

9.1: palladium on carbon; hydrogenchloride; hydrogen / methanol; water / 20 °C

With hydrogenchloride; sodium tetrahydroborate; palladium on carbon; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ozone; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.06.054