2-amino-3-cyano-4-p-fluorophenylpyrrole

Base Information

• Chemical Name: 2-amino-3-cyano-4-p-fluorophenylpyrrole
• CAS No.: 111074-43-2
• Molecular Formula: C₁₁H₈FN₃
• Molecular Weight: 201.203
• Mol file: 111074-43-2.mol

Synonyms:2-amino-3-cyano-4-p-fluorophenylpyrrole

Chemical Property of 2-amino-3-cyano-4-p-fluorophenylpyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-3-cyano-4-p-fluorophenylpyrrole

There total 3 articles about 2-amino-3-cyano-4-p-fluorophenylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-(2-(4-fluorophenyl)-2-oxoethyl)acetamide (451-50-3) + malononitrile (109-77-3) → 2-amino-3-cyano-4-p-fluorophenylpyrrole (111074-43-2)

Guidance literature:

With sodium hydroxide; In methanol; water; 1.) 0 deg C, 15 min; 2.) 60-65 deg C, 35 min;

DOI:10.1002/jhet.5570240201

Reference yield:

2-amino-4'-fluoroacetophenone hydrochloride (456-00-8) → 2-amino-3-cyano-4-p-fluorophenylpyrrole (111074-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / sodium acetate / H₂O / 0 - 10 °C

2: 76 percent / 50percent aq. NaOH / H₂O; methanol / 1.) 0 deg C, 15 min; 2.) 60-65 deg C, 35 min

With sodium hydroxide; sodium acetate; In methanol; water;

DOI:10.1002/jhet.5570240201

Reference yield:

2-Chloro-4'-fluoroacetophenone (456-04-2) → 2-amino-3-cyano-4-p-fluorophenylpyrrole (111074-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) hexamethylenetetramine, sodium iodide; 2.) conc. HCl / 1.) ethanol, chloroform, room temp., 24 h; 2.) ethanol, 50-55 deg C, 4 h

2: 68 percent / sodium acetate / H₂O / 0 - 10 °C

3: 76 percent / 50percent aq. NaOH / H₂O; methanol / 1.) 0 deg C, 15 min; 2.) 60-65 deg C, 35 min

With hydrogenchloride; sodium hydroxide; hexamethylenetetramine; sodium acetate; sodium iodide; In methanol; water;

DOI:10.1002/jhet.5570240201

upstream raw materials:

N-(2-(4-fluorophenyl)-2-oxoethyl)acetamide

malononitrile

2-amino-4'-fluoroacetophenone hydrochloride

2-Chloro-4'-fluoroacetophenone

Downstream raw materials:

1-Benzyl-8-cyano-7-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

1-benzyl-8-cyano-1,4-dihydro-7-p-fluorophenyl-4-oxopyrrolo<1,2-a>pyrimidine-3-carboxylic acid

8-Cyano-7-(4-fluoro-phenyl)-4-oxo-1-prop-2-ynyl-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

1-Allyl-8-cyano-7-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester