451-50-3

Upstream product

• 108-24-7 acetic anhydride 
• 456-00-8 2-amino-4'-fluoroacetophenone hydrochloride 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 

Downstream Products

• 13739-48-5 2-methyl-4-phenyl-imidazole 
• 111074-59-0 1-Benzyl-8-cyano-7-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 111074-49-8 1-benzyl-8-cyano-1,4-dihydro-7-p-fluorophenyl-4-oxopyrrolo<1,2-a>pyrimidine-3-carboxylic acid 
• 111074-58-9 8-Cyano-7-(4-fluoro-phenyl)-4-oxo-1-prop-2-ynyl-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 111074-57-8 1-Allyl-8-cyano-7-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 111074-56-7 8-Cyano-1-ethyl-7-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 111074-45-4 diethyl N-<3-cyano-4-p-fluorophenylpyrrol-2-yl>aminomethylenemalonate 
• 111074-48-7 8-cyano-1,4-dihydro-7-p-fluorophenyl-1-propargyl-4-oxopyrrolo<1,2-a>pyrimidine-3-carboxylic acid 
• 111074-55-6 3-carbethoxy-8-cyano-1,4-dihydro-1-ethyl-7-p-fluorophenyl-4-oxopyrrolo<1,2-a>pyrimidine 
• 111074-67-0 1-Allyl-8-cyano-7-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 
• 111074-66-9 8-Cyano-1-ethyl-7-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 
• 111074-47-6 3-carbethoxy-8-cyano-4-hydroxy-7-p-fluorophenylpyrrolo<1,2-a>pyrimidine 
• 111074-65-8 8-cyano-1,4-dihydro-1-methyl-7-p-fluorophenyl-4-oxopyrrolo<1,2-a>pyrimidine-3-carboxylic acid 
• 447-35-8 N-[(1RS,2RS)-2-(4-fluoro-phenyl)-2-hydroxy-1-hydroxymethyl-ethyl]-acetamide 

Relevant academic research and scientific papers

NEW COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION

The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies. It also relates to use of such compounds, or to methods of use of such compounds.

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 δ/ε INHIBITORS

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE

Inhibitors of dihydroorotate dehydrogenase (DHODH) for the Plasmodium enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.

Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them

A process for producing threo-3-amino-2-hydroxybutanoylaminoacetic acids comprises the steps of allowing to react a starting compound represented by the general formula: STR1 wherein R1 represents a naphthyl or a group of the formula: STR2 in which R6 and R7 represent individually hydrogen, halogen, amino or a protected amino, hydroxy or a protected hydroxy, a lower alkoxy or a lower alkyl and R2 represents a protected amino, with a starting compound represented by the general formula: STR3 wherein R3 represents hydrogen or an ester residue, to obtain threo-3-protected amino-2-hydroxy-4-oxobutanoic acid or its ester represented by the general formula: STR4 wherein R1, R2 and R3 have the same meanings as above, and then reducing the same into threo-3-protected amino-2-hydroxybutanoic acid or its ester represented by the general formula: STR5 wherein R1, R2 and R3 have the same meanings as above, and further converting the above compound into 3-amino-2-hydroxybutanoic acid represented by the general formula: STR6 wherein R2 ' represents amino or a protected amino, thereafter condensing the same, in a conventional manner for forming a peptide coupling, with a compound represented by the general formula: STR7 wherein R4 represents an alkyl having 3-4 carbon atom or 3-guanidinopropyl, while previously protecting as required those groups not relevant to the reaction, and removing the protecting groups for the functional groups to produce threo-3-amino-2-hydroxybutanoylaminoacetic acids represented by the general formula: STR8 wherein R1 and R4 have the same meanings as above. This invention also provides the compounds represented by the general formula (III) as novel intermediates for the above aimed compounds and a process for producing the intermediates.