malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester

Base Information

Chemical Name:malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester
CAS No.:258842-67-0
Molecular Formula:C₄₄H₆₀O₁₂
Molecular Weight:780.953
Hs Code.:

malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester <i>tert</i>-butoxycarbonylmethyl ester

Synonyms:malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester

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Chemical Property of malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester

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Technology Process of malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester

There total 8 articles about malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 50595-15-8
tert-butyl glycolate

: 258842-66-9
malonic acid mono-{3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl} ester

: 258842-67-0
malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 48h;
DOI:10.1016/S0040-4039(99)01996-6

Reference yield:

: 629-11-8
1,6-hexanediol

: 258842-67-0
malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / Ag₂O / CH₂Cl₂ / 4 h / 20 °C

2: 79 percent / PPh₃; CBr₄ / tetrahydrofuran / 0.5 h / 20 °C

3: 52 percent / K₂CO₃ / dimethylformamide / 20 h / 80 °C

4: 99 percent / 3 h / 110 - 120 °C

5: 91 percent / N,N'-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 25 h / 0 - 20 °C

With dmap; carbon tetrabromide; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b003345f

Reference yield:

: 29654-55-5
5-(hydroxymethyl)benzene-1,3-diol

: 258842-67-0
malonic acid 3,5-bis-[6-(4-methoxy-benzyloxy)-hexyloxy]-benzyl ester tert-butoxycarbonylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / K₂CO₃ / dimethylformamide / 20 h / 80 °C

2: 99 percent / 3 h / 110 - 120 °C

3: 91 percent / N,N'-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 25 h / 0 - 20 °C

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b003345f