tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate
CAS No.:1442469-23-9
Molecular Formula:C₂₃H₂₉N₅O₃S
Molecular Weight:455.581
Hs Code.:

Synonyms:tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate

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Chemical Property of tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate

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Technology Process of tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate

There total 6 articles about tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₉ClN₂O₂S

: 219511-71-4
tert-butyl carbamimidoylcarbamate

: 1442469-23-9
tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate

Guidance literature:: In N,N-dimethyl-formamide; at 0 - 65 ℃; for 7h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.04.011

Reference yield:

: 874899-74-8
methyl (2E)-3-{4-[(E)-2-(2-acetamido-1,3-thiazol-4-yl)vinyl]phenyl}acrylate

: 1442469-23-9
tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide; acetic acid / 6 h / 20 °C / 2280.15 Torr

2.1: sodium hydroxide / water; 1,4-dioxane / 2 h / 0 °C

3.1: dichloromethane / 0.08 h / 0 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere; Cooling with ice

4.1: dichloromethane; hexane / 2 h / 0 - 20 °C / Inert atmosphere

4.2: 12 h / 0 - 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 7 h / 0 - 65 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In 1,4-dioxane; hexane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.011

Reference yield:

: 874899-75-9
methyl 3-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenyl}propanoate

: 1442469-23-9
tert-butyl (4-{4-[2-(2-acetamido-1,3-thiazol-4-yl)ethyl]phenethyl}-1H-imidazol-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; 1,4-dioxane / 2 h / 0 °C

2.1: dichloromethane / 0.08 h / 0 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere; Cooling with ice

3.1: dichloromethane; hexane / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 12 h / 0 - 20 °C / Inert atmosphere

4.1: N,N-dimethyl-formamide / 7 h / 0 - 65 °C / Inert atmosphere

With sodium hydroxide; In 1,4-dioxane; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.011