(4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Base Information

Chemical Name:(4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate
CAS No.:869210-31-1
Molecular Formula:C₁₈H₂₅FO₅
Molecular Weight:340.392
Hs Code.:

Synonyms:(4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate

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Technology Process of (4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate

There total 3 articles about (4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 869210-26-4
(2,2-dimethyl-5-oxo-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

: 352-13-6
4-flourophenylmagnesium bromide

: 869210-31-1
(4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: In tetrahydrofuran; for 4h; cooling;
DOI:10.1055/s-2005-872658

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 869210-31-1
(4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: RAMP / benzene / Heating

1.2: t-BuLi / tetrahydrofuran; benzene / -100 °C

1.3: 57 percent / O₃ / tetrahydrofuran; benzene; CH₂Cl₂ / -78 °C

2.1: 98 percent / tetrahydrofuran / 4 h / cooling

With RAMP; In tetrahydrofuran; benzene; 2.1: Grignard reaction;
DOI:10.1055/s-2005-872658

Reference yield:

: 74181-34-3
2,2,-dimethyl-1,3-dioxan-5-one

: 869210-31-1
(4R,5R)-tert-butyl 2-[5-(4-fluorophenyl)-5-hydroxy-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: RAMP / benzene / Heating

1.2: t-BuLi / tetrahydrofuran; benzene / -100 °C

1.3: 57 percent / O₃ / tetrahydrofuran; benzene; CH₂Cl₂ / -78 °C

2.1: 98 percent / tetrahydrofuran / 4 h / cooling

With RAMP; In tetrahydrofuran; benzene; 2.1: Grignard reaction;
DOI:10.1055/s-2005-872658