C₃₄H₄₆O₅

Base Information

• Chemical Name: C₃₄H₄₆O₅
• CAS No.: 1246949-45-0
• Molecular Formula: C₃₄H₄₆O₅
• Molecular Weight: 534.736
• Mol file: 1246949-45-0.mol

Synonyms:C₃₄H₄₆O₅

Chemical Property of C₃₄H₄₆O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₄₆O₅

There total 8 articles about C₃₄H₄₆O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzoic acid (65-85-0,8013-63-6) + 11-ketotigogenin (4802-74-8) → C34H46O5 (1246949-45-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol1019663

Reference yield:

3-OTBS-11-ketotigogenin (1246949-44-9) → C34H46O5 (1246949-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 2: Mitsunobu reaction;

DOI:10.1021/jo102054r

Reference yield:

C39H70O4Si2 (1246949-40-5) → C34H46O5 (1246949-45-0)

Guidance literature:

Multi-step reaction with 6 steps

1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; water / 5 h / 20 °C / Inert atmosphere

2: sodium hydroxide / water; tert-butyl alcohol / 12 h / 80 - 90 °C / Inert atmosphere

3: pyridine / 2.5 h / 135 °C / Inert atmosphere

4: ammonia; calcium / -33 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With pyridine; osmium(VIII) oxide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; ammonia; calcium; 4-methylmorpholine N-oxide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; water; tert-butyl alcohol; 6: Mitsunobu reaction;

DOI:10.1021/jo102054r

upstream raw materials:

benzoic acid

11-ketotigogenin

3-OTBS-11-ketotigogenin

C₃₉H₇₀O₄Si₂

Downstream raw materials:

C₄₁H₅₆O₄

C₄₃H₅₈O₅

(3α,5α,11β,16β)-3,11-bis(benzyloxy)-16-hydroxypregnan-20-one

C₄₇H₆₆O₆