Technology Process of UNC9975
There total 6 articles about UNC9975 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7-(4-bromobutoxy)-3,4-dihydroisoquinolin-1(2H)-one;
With
sodium iodide;
In
acetonitrile;
for 0.5h;
Reflux;
1-(2,3-dichlorophenyl)-1,4-diazepane hydrochloride;
With
potassium carbonate;
In
acetonitrile;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydroxylamine hydrochloride; triethylamine / methanol / 2 h / 20 °C
2.1: dmap; triethylamine / dichloromethane / 20 °C
3.1: methanesulfonyl chloride; boron trifluoride; titanium tetrachloride; methanol / 1,2-dichloro-ethane; methanol / 5 h / 20 °C
3.2: pH 7
4.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice
5.1: potassium carbonate / ethanol / Reflux
6.1: sodium iodide / acetonitrile / 0.5 h / Reflux
6.2: Reflux
With
methanol; dmap; boron trifluoride; hydroxylamine hydrochloride; boron tribromide; titanium tetrachloride; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium iodide;
In
methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice
2.1: potassium carbonate / ethanol / Reflux
3.1: sodium iodide / acetonitrile / 0.5 h / Reflux
3.2: Reflux
With
boron tribromide; potassium carbonate; sodium iodide;
In
ethanol; dichloromethane; acetonitrile;
