(2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol

Base Information

• Chemical Name: (2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol
• CAS No.: 595560-00-2
• Molecular Formula: C₄₆H₅₃NO₅Si
• Molecular Weight: 728.016
• Mol file: 595560-00-2.mol

Synonyms:(2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol

Chemical Property of (2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol

There total 1 articles about (2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(2R,3S,4R,5S)-6-N-benzylhydroxylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol → (2R,3S,4R,5S,6R)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol + (2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol (595560-00-2)

Guidance literature:

With copper diacetate; acetic acid; zinc; In water; at 20 - 70 ℃; for 1h;

DOI:10.1016/S0040-4020(03)00631-8

Reference yield:

(2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol (595560-00-2) → (2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-ethynyl-1,2,3,4,5-hexanepentol (595560-05-7)

Guidance literature:

With sodium hydroxide; In methanol; diethyl ether; water; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(03)00631-8

Reference yield:

(2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-(2-trimethylsilylethynyl)-1,2,3,4,5-hexanepentol (595560-00-2) → (2S,3S,4R,5S,6S)-N-benzyl-3,4,5-tribenzyloxy-6-benzyloxymethyl-2-ethynylpiperidine

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / diethyl ether; methanol; H₂O / 1 h / 20 °C

2: 88 percent / pyridine; molecular sieves 4 Angstroem; MsCl / 100 °C

With pyridine; sodium hydroxide; 4 A molecular sieve; methanesulfonyl chloride; In methanol; diethyl ether; water;

DOI:10.1016/S0040-4020(03)00631-8

Downstream raw materials:

(2R,3S,4R,5S,6S)-6-benzylamino-1,3,4,5-O-tetrabenzyl-6-ethynyl-1,2,3,4,5-hexanepentol