(2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol

Base Information

Chemical Name:(2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol
CAS No.:946615-70-9
Molecular Formula:C₁₃H₁₅F₆NO
Molecular Weight:315.259
Hs Code.:

Synonyms:(2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol

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Chemical Property of (2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol

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Technology Process of (2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol

There total 3 articles about (2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 952795-35-6
4,4,4,4',4',4'-hexafluoro-N-[(1R)-1-phenylethyl]-L-valine phenylmethyl ester

: 946615-70-9
(2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol

Guidance literature:: 4,4,4,4',4',4'-hexafluoro-N-[(1R)-1-phenylethyl]-L-valine phenylmethyl ester; With diisobutylaluminium hydride; In toluene; at -46 - 25 ℃; for 5.5h;

With sodium hydroxide; sodium sulfate; sodium chloride; In water; toluene; at 0 - 45 ℃; for 1.25h;

Reference yield: 99.0%

: 946615-66-3
L-valine, 4,4,4,4',4',4'-hexafluoro-N-[(1R)-1-phenylethyl]-, ethyl ester, hydrochloride

: 946615-70-9
(2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol

Guidance literature:: L-valine, 4,4,4,4',4',4'-hexafluoro-N-[(1R)-1-phenylethyl]-, ethyl ester, hydrochloride; With sodium hydroxide; In toluene; pH=7; Inert atmosphere; Cooling with ice;

With diisobutylaluminium hydride; In toluene; at -46 - 25 ℃; for 5.5h;
DOI:10.1021/jm801252w

Reference yield:

: ethyl 4,4,4,4',4',4'-hexafluoro-N-[(1R)-1-phenylethyl]-L-valinate

: 946615-70-9
(2S)-4,4,4-trifluoro-2-{[(1R)-1-phenylethyl]amino}-3-(trifluoromethyl)butan-1-ol

Guidance literature:: ethyl 4,4,4,4',4',4'-hexafluoro-N-[(1R)-1-phenylethyl]-L-valinate; With diisobutylaluminium hydride; In toluene; at -11 - -8 ℃; for 1.66667h;

With ethanol; In toluene; at -11 - 25 ℃; for 0.166667h;