3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine

Base Information

Chemical Name:3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine
CAS No.:1361392-13-3
Molecular Formula:C₂₂H₃₀N₄O₄S
Molecular Weight:446.571
Hs Code.:

Synonyms:3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine

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Chemical Property of 3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine

Chemical Property:

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Technology Process of 3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine

There total 5 articles about 3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55276-43-2
4-methanesulfonylpiperazine

: 1361392-14-4
3-(4-(benzyloxy)cyclohexyloxy)-6-bromopyridazine

: 1361392-13-3
3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine

Guidance literature:: With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 150 ℃; for 3h; Microwave irradiation;

Reference yield:

: 100-39-0
benzyl bromide

: 1361392-13-3
3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

1.2: 15 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 15 h / 70 °C

3.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 150 °C / Microwave irradiation

With potassium tert-butylate; sodium hydride; caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 556-48-9
1,4-Cyclohexanediol

: 1361392-13-3
3-(4-(benzyloxy)cyclohexyloxy)-6-(4-(methylsulfonyl)piperazin-1-yl)pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

1.2: 15 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 15 h / 70 °C

3.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 150 °C / Microwave irradiation

With potassium tert-butylate; sodium hydride; caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;