(S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile

Base Information

Chemical Name:(S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile
CAS No.:635754-92-6
Molecular Formula:C₄₄H₄₁N₅O
Molecular Weight:655.842
Hs Code.:

Synonyms:(S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile

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Chemical Property of (S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile

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Technology Process of (S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile

There total 3 articles about (S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 17201-43-3
4-cyanobenzyl bromide

: 635754-91-5
(S)-1-benzyl-3-[(1-trityl-imidazol-4-ylmethyl)amino]-azepan-2-one

: 635754-92-6
(S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile

Guidance literature:: (S)-1-benzyl-3-[(1-trityl-imidazol-4-ylmethyl)amino]-azepan-2-one; With sodium hydride; In N,N-dimethyl-formamide; for 1h;

4-cyanobenzyl bromide; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; for 2h;
DOI:10.1016/S0968-0896(03)00218-9

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 635754-92-6
(S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / aq. NaOH / 2-methyl-propan-2-ol / 12 h / 20 °C

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 94 percent / tetrahydrofuran / 2 h / 20 °C

3.1: 95 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

4.1: 81 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 12 h / 20 °C

5.1: NaH / dimethylformamide / 1 h

5.2: 48 percent / NBu₄I / dimethylformamide / 2 h

With sodium hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0968-0896(03)00218-9

Reference yield:

: 380629-65-2
(S)-1-benzyl-2-oxo-3-(tert-butoxycarbonylamino)-azepine

: 635754-92-6
(S)-4-{[(1-trityl-1H-imidazol-4-ylmethyl)-(1-benzyl-2-oxo-azepan-3-yl)-amino]-methyl}-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

2.1: 81 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 12 h / 20 °C

3.1: NaH / dimethylformamide / 1 h

3.2: 48 percent / NBu₄I / dimethylformamide / 2 h

With sodium tris(acetoxy)borohydride; sodium hydride; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00218-9