7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Base Information

Chemical Name:7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl
CAS No.:1621377-69-2
Molecular Formula:C₃₄H₂₁F₃N₃O₄
Molecular Weight:592.554
Hs Code.:

Synonyms:7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

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Chemical Property of 7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

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Technology Process of 7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

There total 6 articles about 7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1621377-83-0
N'-(4-(benzoyloxy)phenyl)-N-[4-(trifluoromethyl)phenyl]-4-(benzoyloxy)benzenecarbohydrazonamide

: 1621377-69-2
7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Guidance literature:: With palladium 10% on activated carbon; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jo500898e

Reference yield:

: 58860-84-7
4-(benzoyloxy)benzoyl chloride

: 1621377-69-2
7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: thionyl chloride / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon / dichloromethane / 20 °C / Inert atmosphere

With thionyl chloride; palladium 10% on activated carbon; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane;
DOI:10.1021/jo500898e

Reference yield:

: 28547-23-1
4-(benzoyloxy)benzoic acid

: 1621377-69-2
7-(trifluoromethyl)-1-(4-(benzoyloxy)phenyl)-3-(4-(benzyloxy)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: thionyl chloride / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 20 °C / Inert atmosphere

5: 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon / dichloromethane / 20 °C / Inert atmosphere

With thionyl chloride; oxalyl dichloride; palladium 10% on activated carbon; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jo500898e