(+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid

Base Information

• Chemical Name: (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid
• CAS No.: 960402-67-9
• Molecular Formula: C₂HF₃O₂*C₂₅H₂₁ClN₂O₃S
• Molecular Weight: 578.996
• Mol file: 960402-67-9.mol

Synonyms:(+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid

Chemical Property of (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid

There total 11 articles about (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-3-{4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (960402-65-7) + trifluoroacetic acid (76-05-1) → (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid (960402-67-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

Reference yield:

5-Chlorothiophene-2-carboxylic acid (24065-33-6) → (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid (960402-67-9)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / ethanol / 0.58 h / Heating / reflux

2: water; trifluoroacetic acid / 4 h

3: trifluorormethanesulfonic acid / 2 h / 95 °C

4: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

5: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 100 °C

6: dichloromethane / 2 h / 20 °C

With pyridine; trifluorormethanesulfonic acid; water; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; copper(l) iodide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; copper diacetate; N,N`-dimethylethylenediamine; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

4,5-dihydro-6H-cyclopenta[b]thiophen-6-one (5650-52-2) → (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid (960402-67-9)

Guidance literature:

Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

2: bromine; acetic acid / 1 h / 0 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 85 °C

4: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

5: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 100 °C

6: dichloromethane / 2 h / 20 °C

With pyridine; hydroxylamine hydrochloride; bromine; sodium acetate; sodium carbonate; caesium carbonate; acetic acid; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; N,N`-dimethylethylenediamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

upstream raw materials:

(+/-)-3-{4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

trifluoroacetic acid

5-Chlorothiophene-2-carboxylic acid

2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

Refernces