(4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester
CAS No.:1433280-02-4
Molecular Formula:C₃₄H₄₀F₃N₅O₈
Molecular Weight:703.716
Hs Code.:

(4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester

Synonyms:(4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester

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Chemical Property of (4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester

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Technology Process of (4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester

There total 8 articles about (4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374892-51-9
[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3-trifluoromethoxy-phenyl]-carbamic acid tert-butyl ester

: 1256390-26-7
((S)-1-{(S)-8-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-1,4-dioxa-7-aza-spiro[4.4]nonane-7-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

: 1433280-02-4
(4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; for 3h; Reflux; Inert atmosphere;

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1433280-02-4
(4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; sodium carbonate / water / 0 - 20 °C

1.2: 1.5 h / pH Ca_. 1

2.1: HATU; triethylamine / dichloromethane / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: toluene-4-sulfonic acid / toluene / Reflux

5.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

5.2: pH 1

6.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

7.1: ammonium acetate / toluene / Reflux

8.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; water; sodium carbonate; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; HATU; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1433280-02-4
(4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: HATU; triethylamine / dichloromethane / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: toluene-4-sulfonic acid / toluene / Reflux

4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

4.2: pH 1

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

6.1: ammonium acetate / toluene / Reflux

7.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; water; sodium carbonate; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;