(S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Base Information

Chemical Name:(S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester
CAS No.:119595-86-7
Molecular Formula:C₃₁H₃₅NO₄
Molecular Weight:485.623
Hs Code.:

Synonyms:(S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Chemical Property of (S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Technology Process of (S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

There total 6 articles about (S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 119595-74-3,119595-77-6
<2S,4(R,S)>-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-methylglutamate

: 119595-94-7
(S)-4-Methyl-1-(9-phenyl-9H-fluoren-9-yl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid tert-butyl ester

: 119595-86-7
(S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

: 119677-62-2
α-tert-butyl (2S,4S)-5-hydroxy-4-methyl-2-N-(9-(9-phenylfluorenyl)amino)pentanoate

: 119595-81-2
α-tert-butyl (2S,4R)-5-hydroxy-4-methyl-2-N-(9-(9-phenylfluorenyl)amino)pentanoate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 4h;
DOI:10.1021/jo00269a022

Reference yield:

: 1499-55-4
L-glutamic acid 5-methyl ester

: 119595-86-7
(S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CHCl₃ / 2 h / Heating

2: lead nitrate, Et₃N / CHCl₃ / 87 h / Ambient temperature

3: 75 percent / CH₂Cl₂ / 16 h / Ambient temperature

4: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) THF, toluene, -78 deg C, 1 h, 2.) THF, toluene, 3 h

With lead(II) nitrate; potassium hexamethylsilazane; triethylamine; In dichloromethane; chloroform;
DOI:10.1021/jo00269a022

Reference yield:

: C₉H₁₉NO₄Si

: 119595-86-7
(S)-2,2-Dimethyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: lead nitrate, Et₃N / CHCl₃ / 87 h / Ambient temperature

2: 75 percent / CH₂Cl₂ / 16 h / Ambient temperature

3: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) THF, toluene, -78 deg C, 1 h, 2.) THF, toluene, 3 h

With lead(II) nitrate; potassium hexamethylsilazane; triethylamine; In dichloromethane; chloroform;
DOI:10.1021/jo00269a022