Technology Process of (R)-1-(3,5-dihydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydro-6-methoxy-2-methylisoquinoline
There total 2 articles about (R)-1-(3,5-dihydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydro-6-methoxy-2-methylisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia; lithium;
In
tetrahydrofuran; methanol; diethyl ether; tert-butyl alcohol;
at -65 - -50 ℃;
for 2.75h;
DOI:10.1002/recl.19831020303
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / sodium cyanotrihydroborate / acetonitrile / 0.01 h / Ambient temperature
2: 98 percent / Li/NH3 (liq.) / tetrahydrofuran; diethyl ether; 2-methyl-propan-2-ol; methanol / 2.75 h / -65 - -50 °C
With
ammonia; lithium; sodium cyanoborohydride;
In
tetrahydrofuran; methanol; diethyl ether; acetonitrile; tert-butyl alcohol;
DOI:10.1002/recl.19831020303
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / cc.HCl / diethyl ether / 48 h / -10 °C
2: 95 percent / 2N NH3 (pH=8)
3: 80 percent / Br2 / aq. acetic acid / 3 h / in the dark
4: 70 percent / Br2 / aq. acetic acid / 3 h / Ambient temperature; in the dark
5: K2CO3 / dimethylformamide / 1 h / 70 °C
6: H2 / 10 percent Pd/C / methanol; aq. acetic acid / 71 h / 55 - 85 °C
With
hydrogenchloride; ammonium hydroxide; hydrogen; bromine; potassium carbonate;
palladium on activated charcoal;
In
methanol; diethyl ether; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/recl.19831020303