(+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:67315-07-5
Molecular Formula:C₃₂H₃₃NO₄
Molecular Weight:495.618
Hs Code.:

Synonyms:(+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 12 articles about (+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 54186-44-6
1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

: 67315-07-5
(+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: (S)-1-(3,5-bis(benzyloxy)-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With formic acid; triethylamine; (+)-(S,S)-TsDPEN-η⁶-p-cymene-Ru^IICl; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 54186-44-6
1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

: 67315-07-5
(+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol5023849

Reference yield:

: 1-<<3,5-Bis(benzyloxy)-4-methoxyphenyl>methyl>-2-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 67315-07-5
(+)-(R)-1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: (S)-1-(3,5-bis(benzyloxy)-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium hydroxide; In ethanol; at 80 ℃; for 15h; Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00081a007