Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:853748-67-1
Molecular Formula:C₄₈H₅₈F₃N₈O₉P
Molecular Weight:979.006
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 12 articles about Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 853748-66-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-(trifluoroacetamido)ethyl)-N⁶-isobutyryladenosine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 853748-67-1
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With pyridine; 4,5-dicyano-1H-imidazole; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jo050061l

Reference yield:

: 304442-35-1
methyl 2-(((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)acetate

: 853748-67-1
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 93 percent / imidazole / dimethylformamide / 16 h

2.1: 94 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

3.1: trimethylsilyl chloride; pyridine / 1 h

3.2: 90 percent / pyridine / 5 h

4.1: 82 percent / Et₃N / CH₂Cl₂ / 1 h

5.1: 97 percent / NaN₃ / dimethylformamide / 3 h / 50 °C

6.1: H₂ / Pd/C / methanol / 1.5 h

7.1: 0.44 g / Et₃N / methanol / 4 h

8.1: 86 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

9.1: 71 percent / pyridine / 24 h / 20 °C

10.1: 73 percent / 4,5-dicyanoimidazole; pyridine / CH₂Cl₂ / 4 h / 20 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; 4,5-dicyano-1H-imidazole; chloro-trimethyl-silane; sodium azide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo050061l

Reference yield:

: 853748-60-4
2-(((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-3-yl)oxy)ethanol

: 853748-67-1
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-isobutyrylamino-purin-9-yl)-4-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: trimethylsilyl chloride; pyridine / 1 h

1.2: 90 percent / pyridine / 5 h

2.1: 82 percent / Et₃N / CH₂Cl₂ / 1 h

3.1: 97 percent / NaN₃ / dimethylformamide / 3 h / 50 °C

4.1: H₂ / Pd/C / methanol / 1.5 h

5.1: 0.44 g / Et₃N / methanol / 4 h

6.1: 86 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

7.1: 71 percent / pyridine / 24 h / 20 °C

8.1: 73 percent / 4,5-dicyanoimidazole; pyridine / CH₂Cl₂ / 4 h / 20 °C

With pyridine; 4,5-dicyano-1H-imidazole; chloro-trimethyl-silane; sodium azide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo050061l