Technology Process of ethyl 5-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)spiro[2.3]hexane-5-carboxylate
There total 6 articles about ethyl 5-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)spiro[2.3]hexane-5-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4’-(trifluoromethyl)biphenyl-3-yl)acetate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 25 ℃;
1,1-bis(bromomethyl)cyclopropane;
In
N,N-dimethyl-formamide;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuryl dichloride / methanol; dichloromethane / 5 h / Reflux
2.1: bromine / chloroform / 1 h / 0 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C
4.1: tetrakis(triphenylphosphine) palladium(0); cesium fluoride / 1,2-dimethoxyethane / 100 °C
5.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 - 20 °C
5.2: 1 h / 0 °C
With
tetrakis(triphenylphosphine) palladium(0); sulfuryl dichloride; bromine; sodium hydride; potassium carbonate; cesium fluoride;
In
methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl-formamide; paraffin oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bromine / chloroform / 1 h / 0 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C
3.1: tetrakis(triphenylphosphine) palladium(0); cesium fluoride / 1,2-dimethoxyethane / 100 °C
4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 - 20 °C
4.2: 1 h / 0 °C
With
tetrakis(triphenylphosphine) palladium(0); bromine; sodium hydride; potassium carbonate; cesium fluoride;
In
1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide; paraffin oil;
