5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one

Base Information

Chemical Name:5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one
CAS No.:135488-37-8
Molecular Formula:C₁₇H₁₉FO₂
Molecular Weight:274.335
Hs Code.:

Synonyms:5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one

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Chemical Property of 5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one

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Technology Process of 5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one

There total 1 articles about 5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 459-57-4
4-fluorobenzaldehyde

: 18679-55-5,66965-44-4,70222-88-7,107598-08-3
(+)-1,3,3-trimethyl-2-oxabicyclo<2.2.2>octan-6-one

: 135488-37-8
5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one

Guidance literature:: With potassium hydroxide; In ethanol; for 12h; Ambient temperature;

Reference yield: 83.0%

: 135488-37-8
5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one

: 135488-34-5
5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one oxime

Guidance literature:: With hydroxylamine hydrochloride; In pyridine; ethanol; for 14h; Heating;

Reference yield:

: 135488-37-8
5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one

: 135488-23-2
5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1,3,3-trimethyl-2-oxa-bicyclo[2.2.2]octan-6-one O-(2-diisopropylamino-ethyl)-oxime

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / NH₂OH*HCl / pyridine; ethanol / 14 h / Heating

2: 1) CH₃ONa / 1) CH₃OH, reflux, 30 min., 2) DMF, a) 50 deg C, 3h, b) RT, 12 h

With hydroxylamine hydrochloride; sodium methylate; In pyridine; ethanol;