N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide

Base Information

Chemical Name:N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide
CAS No.:1321622-29-0
Molecular Formula:C₃₇H₅₉N₃O₆
Molecular Weight:641.892
Hs Code.:

Synonyms:N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide

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Chemical Property of N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide

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Technology Process of N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide

There total 8 articles about N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

: 1321622-47-2
N-(3-((2S,4S,5S,7S)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl nonanamido)-2,2-dimethylpropyl)benzamide

: 1321622-29-0
N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; ethanolamine; In tert-butyl methyl ether; at 25 ℃;
DOI:10.1016/j.bmc.2011.05.059

Reference yield:

: 1321622-81-4
N-(3-azido-2,2-dimethylpropyl)benzamide

: 1321622-29-0
N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 25 °C

2: 2-hydroxypyridin; triethylamine / 65 °C

3: palladium 10% on activated carbon; hydrogen; ethanolamine / tert-butyl methyl ether / 25 °C

With 2-hydroxypyridin; palladium 10% on activated carbon; hydrogen; ethanolamine; triethylamine; In methanol; tert-butyl methyl ether;
DOI:10.1016/j.bmc.2011.05.059

Reference yield:

: 111992-61-1
2-(3-bromo-2, 2-dimethylpropyl)-2,3-dihydro-1H-isoindole-1,3-dione

: 1321622-29-0
N-(3-((2S,4S,5S,7S)-5-amino-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamido)-2,2-dimethylpropyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 8 h / 100 °C

2: hydrazine hydrate / ethanol / 4 h / 80 °C

3: triethylamine / dichloromethane / 0 - 25 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 25 °C

5: 2-hydroxypyridin; triethylamine / 65 °C

6: palladium 10% on activated carbon; hydrogen; ethanolamine / tert-butyl methyl ether / 25 °C

With 2-hydroxypyridin; sodium azide; palladium 10% on activated carbon; hydrogen; hydrazine hydrate; ethanolamine; triethylamine; In methanol; ethanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.059