(E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide

Base Information

Chemical Name:(E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide
CAS No.:1126793-06-3
Molecular Formula:C₂₀H₂₃IN₂O₂
Molecular Weight:450.319
Hs Code.:

Synonyms:(E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide

Suppliers and Price of (E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide

There total 8 articles about (E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154225-11-3
N-(4-phenyl-1-buten-4-yl)-2-iodobenzenamine

: 1126793-06-3
(E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 0.33 h / -78 °C

2.1: water; osmium(VIII) oxide / ethanol / 0.25 h / Darkness

3.1: sodium periodate / ethanol; water / 2 h

4.1: dichloromethane / 24 h / 20 °C

With sodium periodate; osmium(VIII) oxide; water; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; 4.1: |Wittig Olefination;
DOI:10.1002/ejoc.201300048

Reference yield:

: 615-43-0
2-iodophenylamine

: 1126793-06-3
(E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether / 18 h / Molecular sieve; Reflux

2.1: tetrahydrofuran / -78 - -42 °C / Inert atmosphere

2.2: -42 °C / Inert atmosphere

3.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: 0.33 h / -78 °C

4.1: water; osmium(VIII) oxide / ethanol / 0.25 h / Darkness

5.1: sodium periodate / ethanol; water / 2 h

6.1: dichloromethane / 24 h / 20 °C

With sodium periodate; osmium(VIII) oxide; water; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; 6.1: |Wittig Olefination;
DOI:10.1002/ejoc.201300048

Reference yield:

: 15111-14-5
2-iodo-N-(phenylmethylene)-benzenamine

: 1126793-06-3
(E)-5-[(2-iodophenyl)(methyl)amino]-N-methoxy-N-methyl-5-phenylpent-2-enamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / -78 - -42 °C / Inert atmosphere

1.2: -42 °C / Inert atmosphere

2.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 0.33 h / -78 °C

3.1: water; osmium(VIII) oxide / ethanol / 0.25 h / Darkness

4.1: sodium periodate / ethanol; water / 2 h

5.1: dichloromethane / 24 h / 20 °C

With sodium periodate; osmium(VIII) oxide; water; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; 5.1: |Wittig Olefination;
DOI:10.1002/ejoc.201300048