(1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane

Base Information

• Chemical Name: (1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane
• CAS No.: 840454-59-3
• Molecular Formula: C₃₉H₄₄ClO₄P
• Molecular Weight: 643.203

Synonyms:(1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane

Chemical Property of (1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane

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Technology Process of (1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane

There total 1 articles about (1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate (59779-75-8) → (1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane (840454-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; iodine / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 12 h / Inert atmosphere; Reflux

2.1: phosphorus trichloride; triethylamine / tetrahydrofuran / 0 °C / Schlenk technique; Inert atmosphere

With iodine; magnesium; triethylamine; phosphorus trichloride; In tetrahydrofuran;

DOI:10.1021/jacs.8b02547

Reference yield: 89.0%

(1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane (840454-59-3) + C32H28N2O3 → C71H71N2O7P

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1039/c1cc16146f

Reference yield: 87.0%

(1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane (840454-59-3) + C32H28N2O3 → C71H71N2O7P

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1039/c1cc16146f

upstream raw materials:

diethyl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate

Downstream raw materials:

3-{[(3aR,8aR)-4,4,8,8-tetrakis(3,5-dimethylphenyl)-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]oxy}propanenitrile

(3,5-dimethylphenyl-TADDOL)P(indoline)

(R)-2-(2,3,4,5-tetrahydrobenzo[b]oxepin-3-yl)acetic acid tert-butyl ester

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