Chemical Property of PRL-3 Inhibitor
Chemical Property:
- PSA：95.72000
- LogP:5.60820
- Storage Temp.:−20°C
- Solubility.:DMSO: >10mg/mL
- XLogP3:5.6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:4
- Exact Mass:484.85775
- Heavy Atom Count:24
- Complexity:529
- Purity/Quality:
-
97% *data from raw suppliers
PRL-3 Inhibitor *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi,N
- Statements:
36/37/38-50/53
- Safety Statements:
26-36/37-60-61
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)C=C3C(=O)NC(=S)S3)Br
- Isomeric SMILES:C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)/C=C\3/C(=O)NC(=S)S3)Br
- Recent EU Clinical Trials:A Prospective Multicenter Phase III Clinical Evaluation of the Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress Echocardiography with Dobutamine for the Diagnosis of Coronary Artery Disease
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Description
P0108 (893449-38-2) is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 μM.1? Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.2 Sensitizes PRL-3-expressing cancer cells to chemotherapeutics.3 Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells.4
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Uses
5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone is a a cell-permeable benzylidene rhodamine that inhibits Phosphatase of regenerating liver 3 (PRL-3).
