7-CHLOROQUINOLINE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID
• CAS No.: 892874-49-6
• Molecular Formula: C₁₀H₆ClNO₂
• Molecular Weight: 207.616
• Hs Code.: 2933499090
• Mol file: 892874-49-6.mol

Synonyms:7-Chloroquinoline-3-carboxylic acid;

Chemical Property of 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.69
• Boiling Point: 382.122 °C at 760 mmHg
• PKA: 4.39±0.25(Predicted)
• Flash Point: 184.901 °C
• PSA: 50.19000
• Density: 1.47 g/cm³
• LogP: 2.58640
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Chloro-3-quinolinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Chloro-3-quinolinecarboxylic Acid is used as a reactant in the preparation of N-(het)arylmethyl)heteroaryl-carboxamides as plasma kallikrein inhibitors.

Technology Process of 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID

There total 3 articles about 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

7-chloro-quinoline-3-carboxylic acid ethyl ester (133455-49-9) → 7-chloroquinoline-3-carboxylic acid (892874-49-6)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

Reference yield:

4-chloro-2-nitrotoluene (89-59-8) → 7-chloroquinoline-3-carboxylic acid (892874-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 48 h / 135 °C

2: tin(ll) chloride / ethanol / 4 h / 90 °C

3: sodium hydroxide; water / methanol / 3 h / 20 °C

With water; N,N-dimethyl-formamide dimethyl acetal; tin(ll) chloride; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

4-Chloro-2-nitrobenzaldehyde (5551-11-1) → 7-chloroquinoline-3-carboxylic acid (892874-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(ll) chloride / ethanol / 4 h / 90 °C

2: sodium hydroxide; water / methanol / 3 h / 20 °C

With water; tin(ll) chloride; sodium hydroxide; In methanol; ethanol;

upstream raw materials:

4-chloro-2-nitrotoluene

4-Chloro-2-nitrobenzaldehyde

7-chloro-quinoline-3-carboxylic acid ethyl ester

Refernces