133455-49-9

Usage

Uses

Used in Pharmaceutical Industry:
7-Chloroquinoline-3-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of potential drug candidates for the treatment of various diseases. Its unique structure and properties contribute to the development of new drugs with therapeutic applications.
Used in Research and Development:
7-Chloroquinoline-3-carboxylic acid ethyl ester is utilized in various research and development processes for the synthesis of new chemical compounds with potential biological activity. Its versatility and reactivity make it a valuable component in the creation of novel compounds with potential applications in medicine and other fields.

Upstream product

• 89-59-8 4-chloro-2-nitrotoluene 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 1001-26-9 ethyl 3-ethoxyacrylate 
• 27032-10-6 4-chlorobenzyl azide 
• 622-95-7 4-chlorobenzyl bromide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 10601-80-6 ethyl 3,3-diethoxypropanoate 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 59236-37-2 2-amino-4-chlorobenzaldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 451491-95-5 (E)-3-(4-Chloro-phenyl)-2-[(toluene-4-sulfonylamino)-methyl]-acrylic acid ethyl ester 
• 352521-42-7 2-[(2,4-dichloro-phenyl)-(toluene-4-sulfonylamino)-methyl]-acrylic acid ethyl ester 

Downstream Products

• 892874-49-6 7-chloroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of 3-quinolinecarboxylic acid esters from the Baylis-Hillman adducts of 2-halobenzaldehyde N-tosylimines

3-Quinolinecarboxylic acid ethyl esters 4 were prepared from 1, the Baylis-Hillman adducts of o-halobenzaldehyde N-tosylimines, in a one-pot reaction.

A 3 - amino -7 - chloroquinolin synthetic method (by machine translation)

The invention provides a 3 - amino - 7 - chloroquinolin synthetic method. Synthesis method of the invention, in order to 4 - chloro - 1 - methyl - 2 - nitrobenzene as the raw materials, and N, N - dimethyl formamide dimethyl acetal to hydroformylation reaction to produce 4 - chloro - 2 - nitrobenzaldehyde, with 3, 3 - diethyl oxygen radical propionic acid ethyl ester to ring-closure reaction to produce 7 - chloro - 3 - quinoline carboxylic acid ethyl ester, under basic condition to produce 7 - chloro - 3 - quinoline carboxylic acid, with the azido diphenyl phosphate through Curtius rearrangement reaction to 3 - tert-butoxycarbonyl amino - 7 - chloroquinolin, finally through takes off uncle butoxycarbonyl to obtain 3 - amino - 7 chloroquinolin. The invention of 3 - amino - 7 - chloroquinolin synthetic method, the synthetic route is simple, reasonable process, low material cost, simple and easy to obtain, operation and after treatment is convenient, the total yield is high, easy to enlarge, can be large-scale production of 3 - amino - 7 - chloroquinolin. (by machine translation)

Copper-catalyzed domino SN2′/coupling reaction: A versatile and facile synthesis of cyclic compounds from baylis-hillman acetates

A variety of substituted quinoline/pyridine, thiochromene and naphthalene derivatives, which might be of biological and medicinal value, were synthesized by copper-catalyzed domino SN2′/coupling, SN2′ /deacylation/coupling and SN2′/coupling/elimination reactions. The method provides a general and convenient approach to the synthesis of various substituted cyclic compounds from the corresponding Baylis-Hillman (B-H) acetates and N-/S-/C-nucleophiles. Copyright

Synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters from arylmethyl azides via a domino process

A convenient synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters via a domino process is described. The synthesis employs arylmethyl azides as the precursor which undergoes an acid-promoted rearrangement to give an N-aryl iminium ion. Following the addition with ethyl 3-ethoxyacrylate, intramolecular electrophilic aromatic substitution, elimination and subsequent oxidation, the quinoline products were obtained in moderate to excellent yields.

A one-step synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid esters from o -nitrobenzaldehydes

A straightforward and efficient one-step procedure for the synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters is described. The simple reductive cyclization is carried out by treating various substituted o-nitrobenzaldehydes with inex

Methods of making quinoline amides

The present invention relates to methods of making quinoline amides of Formula I below, which are microsomal triglyceride transfer protein inhibitors and can be used as medicines. The present invention also relates to compounds that are used to make quino

7[4′-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B

This invention relates to compounds of Formula I that inhibit the secretion of apolipoprotein B, to pharmaceutical compositions comprising the compounds, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperliproproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia, pancreatitis, myocardial infarction, stroke, restenosis, or Syndrome X. This invention also relates to methods of reducing the secretion of apolipoprotein B and/or inhibiting microsomal triglyceride transfer protein.

Synthesis of quinolines from the Baylis-Hillman acetates via the oxidative cyclization of sulfonamidyl radical as the key step

Ethyl 3-quinolinecarboxylates 5 were synthesized in good to moderate yields from the Baylis-Hillman acetates 1 via the oxidative cyclization reaction of the N-tosylamidyl radical, which was generated from the rearranged tosylamide derivatives 2 by iodoben