5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal

Base Information

• Chemical Name: 5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal
• CAS No.: 98454-57-0
• Molecular Formula: C₂₀H₂₇N₅O₅
• Molecular Weight: 417.465

Synonyms:5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal

Chemical Property of 5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal

Chemical Property:

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Technology Process of 5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal

There total 2 articles about 5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-hydroxy-2-nitrobenzaldehyde ethylene acetal (98454-56-9) + 1-cyclohexyl-5-(4-chlorobutyl)-1,2,3,4-tetrazole (73963-42-5) → 5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal (98454-57-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 6h;

DOI:10.1248/cpb.33.1140

Reference yield:

2-nitro-5-hydroxybenzaldehyde (42454-06-8) → 5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal (98454-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / triethylorthoformate, TsOH / 1 h / Heating

2: 87 percent / K₂CO₃ / dimethylformamide / 6 h / 120 °C

With potassium carbonate; toluene-4-sulfonic acid; orthoformic acid triethyl ester; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.1140

Reference yield: 86.0%

5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal (98454-57-0) → 5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde (98454-58-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 50 ℃; for 1h;

DOI:10.1248/cpb.33.1140

upstream raw materials:

5-hydroxy-2-nitrobenzaldehyde ethylene acetal

1-cyclohexyl-5-(4-chlorobutyl)-1,2,3,4-tetrazole

2-nitro-5-hydroxybenzaldehyde

Downstream raw materials:

5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde

OPC-13326

ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

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