O₆-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine

Base Information

• Chemical Name: O₆-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine
• CAS No.: 1030006-32-6
• Molecular Formula: C₃₁H₅₀N₄O₆SSi₂
• Molecular Weight: 662.998

Synonyms:O₆-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine

Chemical Property of O₆-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine

Chemical Property:

Purity/Quality:

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Technology Process of O₆-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine

There total 3 articles about O₆-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2-mesitylenesulphonyl chloride (773-64-8) + 3′,5′-bis-O-(tert-butyldimethylsilyl)-2′-deoxyinosine (106568-83-6) → O6-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine (1030006-32-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → O6-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine (1030006-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 1.5 h / 20 °C

With 1H-imidazole; dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-deoxyinosine (890-38-0) → O6-(2-mesitylenesulfonyl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyinosine (1030006-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 1.5 h / 20 °C

With 1H-imidazole; dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyldimethylsilyl chloride

2-mesitylenesulphonyl chloride

3′,5′-bis-O-(tert-butyldimethylsilyl)-2′-deoxyinosine

2-deoxyinosine

Downstream raw materials:

N₆-[1-(4-iodophenyl)ethyl]-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyadenosine

N₆-[1-(4-iodophenyl)ethyl]-2'-deoxyadenosine

N₆-{1-[4-(3-trifluoroacetamido-1-propynyl)phenyl]ethyl}-2'-deoxyadenosine

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