(2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol

Base Information

• Chemical Name: (2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol
• CAS No.: 769196-63-6
• Molecular Formula: C₁₂H₁₄ClIO₃
• Molecular Weight: 368.599

Synonyms:(2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol

Chemical Property of (2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol

Chemical Property:

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Technology Process of (2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol

There total 2 articles about (2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-bromomethyl-4-chlorostyrene (89220-51-9) → (2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol (769196-63-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Zn; SnCl₂ / H₂O / 0.5 h / 20 °C

2: HCl / H₂O / 2 h / 20 °C

3: 84 percent / I₂; NaHCO₃ / acetonitrile / 8 h / cooling

With hydrogenchloride; iodine; sodium hydrogencarbonate; tin(ll) chloride; zinc; In water; acetonitrile;

DOI:10.1021/ol049008u

Reference yield:

(S)-3-(4-chlorophenyl)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-1-ol (769196-55-6) → (2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol (769196-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / H₂O / 2 h / 20 °C

2: 84 percent / I₂; NaHCO₃ / acetonitrile / 8 h / cooling

With hydrogenchloride; iodine; sodium hydrogencarbonate; In water; acetonitrile;

DOI:10.1021/ol049008u

Reference yield: 87.0%

(2R,3S,5R)-5-(4-chlorophenyl)-tetrahydro-2-(hydroxymethyl)-5-(iodomethyl)furan-3-ol (769196-63-6) → (1R,5R,6S)-1-(4-chlorophenyl)-6-hydroxyl-3,8-dioxabicyclo[3.2.1]octane

Guidance literature:

With potassium carbonate; silver nitrate; In methanol; at 20 ℃; for 2h;

DOI:10.1021/ol049008u

upstream raw materials:

α-bromomethyl-4-chlorostyrene

(S)-3-(4-chlorophenyl)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-1-ol

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