N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide

Base Information

Chemical Name:N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide
CAS No.:1356483-62-9
Molecular Formula:C₁₈H₁₉F₂N₃O₂
Molecular Weight:347.365
Hs Code.:

Synonyms:N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide

Chemical Property:

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Technology Process of N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide

There total 6 articles about N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356483-60-7
5-(2-hydroxypropan-2-yl)pyridine-3-carboxylic acid

: 1356483-58-3
N¹‐cyclopropyl‐4,5‐difluorobenzene‐1,2‐diamine

: 1356483-62-9
N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 2105-61-5
1,2,4-trifluoro-5-nitrobenzene

: 1356483-62-9
N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium fluoride / water / 0.17 h / 90 °C / Microwave irradiation

2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C

With potassium fluoride; 1-hydroxy-7-aza-benzotriazole; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; water;

Reference yield:

: 40472-88-6
3-bromo-5-(hydroxyisopropyl)pyridine

: 1356483-62-9
N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 70 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 0.5 h / 20 °C

2.2: pH ~ 2

3.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; dichloromethane;