40472-88-6

Basic information

• Product Name: 3-BroMo-5-(prop-1-en-2-yl)pyridine
• Synonyms: 2-(5-broMopyridin-3-yl)propan-2-ol;2-(5-Bromo-3-Pyridinyl)-2-Propanol;3-BroMo-5-(prop-1-en-2-yl)pyridine;EOS-62120
• CAS NO: 40472-88-6
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 198.05982
• Product Categories: Heterocycle-Pyridine series
• Mol File: 40472-88-6.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-BroMo-5-(prop-1-en-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-5-(prop-1-en-2-yl)pyridine(40472-88-6)
• EPA Substance Registry System: 3-BroMo-5-(prop-1-en-2-yl)pyridine(40472-88-6)

Safety Data

• Hazardous Substances Data: 40472-88-6(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-(prop-1-en-2-yl)pyridine is an organic compound with the molecular formula C8H8BrN. It is a brominated derivative of pyridine, characterized by the presence of a bromine atom and a prop-1-en-2-yl group on the five-carbon position of the pyridine ring. This chemical is commonly used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceuticals and agrochemicals. It is also utilized as a reagent in the synthesis of heterocyclic compounds. 3-Bromo-5-(prop-1-en-2-yl)pyridine is a colorless to light yellow liquid, with a strong, pungent odor, and it should be handled with care due to its potential hazards, such as being flammable and toxic if ingested or absorbed through the skin.

Upstream product

• 39620-02-5 5-bromonicotinoyl chloride 
• 917-64-6 methyl magnesium iodide 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 
• 75-16-1 methylmagnesium bromide 
• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 625-92-3 3,5-dibromopyridine 
• 67-64-1 acetone 
• 38940-62-4 3-acetyl-5-bromopyridine 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 

Downstream Products

• 118775-69-2 3-bromo-5-isopropenylpyridine 
• 1356483-54-9 5-(2-hydroxypropan-2-yl)pyridine-3-carbaldehyde 
• 1356483-62-9 N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide 
• 1386874-06-1 LY3023414 

Relevant articles and documents

Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension

We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus related steroidal and hepatic CYP targets, and lead-like physical and pharmacokinetic properties. On the basis of these and other data, the indazole series was progressed to lead optimization for further refinement.

INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.

IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to imidazopyridyl compounds of the structural formula: I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.