40472-88-6

Usage

Uses

Used in Organic Synthesis:
3-Bromo-5-(prop-1-en-2-yl)pyridine is used as a building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its unique structure allows for further functionalization and modification, making it a versatile intermediate in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-Bromo-5-(prop-1-en-2-yl)pyridine is used as a key intermediate for the development of new drugs. Its presence in the molecular structure can impart specific biological activities, such as anti-inflammatory, antimicrobial, or anticancer properties, depending on the final compound synthesized.
Used in Synthesis of Heterocyclic Compounds:
3-Bromo-5-(prop-1-en-2-yl)pyridine is also utilized as a reagent in the synthesis of heterocyclic compounds. Its ability to form various heterocyclic rings makes it a valuable component in the development of novel chemical entities with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Chemical Research:
In addition to its practical applications, 3-Bromo-5-(prop-1-en-2-yl)pyridine is also used in chemical research to explore new synthetic routes, reaction mechanisms, and the development of innovative catalysts and methodologies. Its unique structural features make it an interesting subject for academic and industrial research.

Upstream product

• 39620-02-5 5-bromonicotinoyl chloride 
• 917-64-6 methyl magnesium iodide 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 
• 75-16-1 methylmagnesium bromide 
• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 625-92-3 3,5-dibromopyridine 
• 67-64-1 acetone 
• 38940-62-4 3-acetyl-5-bromopyridine 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 

Downstream Products

• 1356483-54-9 5-(2-hydroxypropan-2-yl)pyridine-3-carbaldehyde 
• 1356483-62-9 N-[2-(cyclopropylamino)-4,5-difluorophenyl]-5-(2-hydroxypropan-2-yl)pyridine-3-carboxamide 
• 1386874-06-1 LY3023414 
• 118775-69-2 3-bromo-5-isopropenylpyridine 

Relevant academic research and scientific papers

Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension

We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus related steroidal and hepatic CYP targets, and lead-like physical and pharmacokinetic properties. On the basis of these and other data, the indazole series was progressed to lead optimization for further refinement.

Discovery of benzimidazole CYP11B2 inhibitors with in vivo activity in rhesus monkeys

We report the discovery of a benzimidazole series of CYP11B2 inhibitors. Hit-to-lead and lead optimization studies identified compounds such as 32, which displays potent CYP11B2 inhibition, high selectivity versus related CYP targets, and good pharmacokin

INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.

PYRAZOLOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to pyrazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone s

IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to imidazopyridyl compounds of the structural formula: I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

TRIAZOLOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to triazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

PI3 KINASE/mTOR DUAL INHIBITOR

The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.

ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

ALDOSTERONE SYNTHASE INHIBITORS

The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.

5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1

The present invention provides a compound a formula (I); or a pharmaceutically acceptable salt thereof, wherein: X is CH2, O, S or-NR1; each R1 are independently C1-7alkyl or C3-8cycloalkyl; each of R