(+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate

Base Information

• Chemical Name: (+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate
• CAS No.: 1350724-64-9
• Molecular Formula: C₃₂H₅₄O₆
• Molecular Weight: 534.777
• Mol file: 1350724-64-9.mol

Synonyms:(+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate

Chemical Property of (+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate

There total 4 articles about (+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-(1',1'-dimethyl-n-heptyl)-1,3-dihydroxybenzene (56469-10-4) + (+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-bromoundecanoate → (+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate (1350724-64-9)

Guidance literature:

5-(1',1'-dimethyl-n-heptyl)-1,3-dihydroxybenzene; With potassium fluoride; potassium carbonate; In acetone; for 0.5h; Reflux; Inert atmosphere;

(+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-bromoundecanoate; In acetone; for 48h; Reflux; Inert atmosphere;

DOI:10.1021/jm200529h

Reference yield:

11-bromoundecanoic acid (2834-05-1) → (+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate (1350724-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: potassium fluoride; potassium carbonate / acetone / 0.5 h / Reflux; Inert atmosphere

2.2: 48 h / Reflux; Inert atmosphere

With dmap; potassium fluoride; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetone;

DOI:10.1021/jm200529h

Reference yield:

1-(1',1'-dimethylheptyl)-3,5-dimethoxybenzene (60526-81-0) → (+/-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate (1350724-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane

2.1: potassium fluoride; potassium carbonate / acetone / 0.5 h / Reflux; Inert atmosphere

2.2: 48 h / Reflux; Inert atmosphere

With potassium fluoride; boron tribromide; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/jm200529h

upstream raw materials:

11-bromoundecanoic acid

5-(1',1'-dimethyl-n-heptyl)-1,3-dihydroxybenzene

1-(1',1'-dimethylheptyl)-3,5-dimethoxybenzene

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

Downstream raw materials:

2,3-dihydroxypropyl 11-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]undecanoate