5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester

Base Information

• Chemical Name: 5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester
• CAS No.: 125878-24-2
• Molecular Formula: C₂₃H₄₀O₄Si
• Molecular Weight: 408.654
• Mol file: 125878-24-2.mol

Synonyms:5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester

Chemical Property of 5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester

There total 5 articles about 5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-benzyloxypentanoic acid (64740-39-2) + 5-(tert-butyldimethyl-silyloxy)pentan-1-ol (83067-20-3) → 5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester (125878-24-2)

Guidance literature:

With dmap; camphor-10-sulfonic acid; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 4h;

DOI:10.1021/ja00164a026

Reference yield:

1 ,5-pentanediol (111-29-5) → 5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester (125878-24-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 0 deg, 2.) 25 deg C, 5 h

2: 93 percent / CrO₃, H₂SO₄ (Jones' reagent) / acetone / 1 h / 0 °C

3: 70 percent / 1,3-dicyclohexylcarbodiimide (DCC), 4-(dimethylamino)pyridine (DMAP), camphorsulfonic acid (CSA) / CH₂Cl₂ / 4 h / 25 °C

With chromium(VI) oxide; dmap; sulfuric acid; camphor-10-sulfonic acid; sodium hydride; dicyclohexyl-carbodiimide; In dichloromethane; acetone;

DOI:10.1021/ja00164a026

Reference yield:

5-(benzyloxy)-1-pentanol (4541-15-5) → 5-Benzyloxy-pentanoic acid 5-(tert-butyl-dimethyl-silanyloxy)-pentyl ester (125878-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / CrO₃, H₂SO₄ (Jones' reagent) / acetone / 1 h / 0 °C

2: 70 percent / 1,3-dicyclohexylcarbodiimide (DCC), 4-(dimethylamino)pyridine (DMAP), camphorsulfonic acid (CSA) / CH₂Cl₂ / 4 h / 25 °C

With chromium(VI) oxide; dmap; sulfuric acid; camphor-10-sulfonic acid; dicyclohexyl-carbodiimide; In dichloromethane; acetone;

DOI:10.1021/ja00164a026

upstream raw materials:

5-benzyloxypentanoic acid

5-(tert-butyldimethyl-silyloxy)pentan-1-ol

1 ,5-pentanediol

5-(benzyloxy)-1-pentanol