(R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

Base Information

Chemical Name:(R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate
CAS No.:127633-55-0
Molecular Formula:C₁₈H₃₁BrO₄SSi
Molecular Weight:451.497
Hs Code.:

Synonyms:(R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

Chemical Property:

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Technology Process of (R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

There total 10 articles about (R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 127633-54-9
(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

: 124-63-0
methanesulfonyl chloride

: 127633-55-0
(R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(01)93875-4

Reference yield:

: 124-63-0
methanesulfonyl chloride

: (RS)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol

: 127633-55-0
(R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

: (S)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; for 0.583333h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00102a031

Reference yield:

: 4654-39-1
4-bromophenethanol

: 127633-55-0
(R)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N

2: 90 percent / NaH

3: 75 percent / LiAlH₄ / diethyl ether

4: 90 percent / with porcine pancreatic lipase (PPL, Sigma type II, no. 3126)

5: 88 percent / imidazole / CH₂Cl₂

6: 79 percent / aq. NaOH / 25 °C

7: 85 percent / Et₃N / CH₂Cl₂

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; sodium hydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(01)93875-4