(2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one)

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Chemical Name:(2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one)
CAS No.:1190630-27-3
Molecular Formula:C₄₀H₄₄O₁₁
Molecular Weight:700.783
Hs Code.:

Synonyms:(2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one)

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Chemical Property of (2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one)

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Technology Process of (2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one)

There total 6 articles about (2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094854-03-1
(S)-1-(3,4-dimethoxyphenyl)-1-oxopropan-2-yl-4-methylbenzenesulfonate

: 1190630-26-2
C₁₈H₂₀O₅

: 1190630-27-3
(2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one)

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In dichloromethane;

Reference yield:

: C₃₀H₄₈O₆Si₂

: 1190630-27-3
(2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one)

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate; sodium cyanoborohydride / dichloromethane; acetonitrile / 1 h / -78 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

3.1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 - 25 °C / Inert atmosphere

With boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium cyanoborohydride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.0c00151

Reference yield:

: 1491173-73-9
1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol

: 1190630-27-3
(2R,2'R)-2,2'-((((2S,5S)-tetrahydrofuran-2,5-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(1-(3,4-dimethoxyphenyl)propan-1-one)

Guidance literature:: Multi-step reaction with 8 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 0.5 h / 110 °C / Inert atmosphere

2.1: polymethylhydrosiloxane / toluene / 12 h / 130 °C / Inert atmosphere

3.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene; tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / toluene / 12 h / 70 °C / Inert atmosphere

5.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

6.1: boron trifluoride diethyl etherate; sodium cyanoborohydride / dichloromethane; acetonitrile / 1 h / -78 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

8.1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

8.2: 1 h / 0 - 25 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dimethylsulfide borane complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tert.-butyl lithium; pyridinium p-toluenesulfonate; sodium cyanoborohydride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; pentane; 1.1: |Cross Metathesis / 3.1: |Corey-Bakshi-Shibata Reduction;
DOI:10.1021/acs.jmedchem.0c00151