1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol

Base Information

• Chemical Name: 1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol
• CAS No.: 1491173-73-9
• Molecular Formula: C₁₆H₂₆O₃Si
• Molecular Weight: 294.466
• Mol file: 1491173-73-9.mol

Synonyms:1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol

Chemical Property of 1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol

There total 6 articles about 1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-one → 1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol (1491173-73-9)

Guidance literature:

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; In methanol; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c7ob02697h

Reference yield: 81.0%

O-tert-butyldimethylsilylvanillin (69404-94-0) + vinyl magnesium bromide (1826-67-1) → 1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol (1491173-73-9)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1.83h; Inert atmosphere;

DOI:10.1002/anie.201302317

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol (1491173-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / N,N-dimethyl-formamide / Inert atmosphere

2: tetrahydrofuran / 1.83 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/anie.201302317

upstream raw materials:

tert-butyldimethylsilyl chloride

O-tert-butyldimethylsilylvanillin

vinyl magnesium bromide

vanillin