methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate

Base Information

Chemical Name:methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate
CAS No.:1435935-56-0
Molecular Formula:C₃₆H₃₆O₉
Molecular Weight:612.676
Hs Code.:

Synonyms:methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate

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Chemical Property of methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate

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Technology Process of methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate

There total 7 articles about methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 143096-38-2
methyl 6-bromo-3-formyl-2-methoxybenzoate

: 1435935-55-9
3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-ol

: 1435935-56-0
methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate

Guidance literature:: With dmap; copper; copper(II) oxide; In acetonitrile; Inert atmosphere; Reflux;
DOI:10.1002/cjoc.201200977

Reference yield:

: 1435935-54-8
3-(benzyloxy)-5-(hydroxymethyl)-4'-methoxy-[1,1'-biphenyl]-4-ol

: 1435935-56-0
methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 0.25 h / -10 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: copper; copper(II) oxide; dmap / acetonitrile / Inert atmosphere; Reflux

With dmap; copper; toluene-4-sulfonic acid; copper(II) oxide; In dichloromethane; acetonitrile;
DOI:10.1002/cjoc.201200977

Reference yield:

: 86734-59-0
3-benzyloxy-2-hydroxybenzaldehyde

: 1435935-56-0
methyl 6-((3-(benzyloxy)-4'-methoxy-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-[1,1'-biphenyl]-4-yl)oxy)-3-formyl-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; ammonium acetate / acetonitrile / 4 h / 25 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol / 4 h / 80 °C / Inert atmosphere

3.1: methanol; sodium tetrahydroborate / 0 - 20 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 0.25 h / -10 °C / Inert atmosphere

4.2: 25 °C / Inert atmosphere

5.1: copper; copper(II) oxide; dmap / acetonitrile / Inert atmosphere; Reflux

With methanol; dmap; sodium tetrahydroborate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; copper; potassium carbonate; toluene-4-sulfonic acid; copper(II) oxide; In methanol; dichloromethane; acetonitrile; 2.1: |Suzuki Coupling;
DOI:10.1002/cjoc.201200977