3-Benzyloxy-2-hydroxy benzaldehyde

Base Information

• Chemical Name: 3-Benzyloxy-2-hydroxy benzaldehyde
• CAS No.: 86734-59-0
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• European Community (EC) Number: 832-724-5
• DSSTox Substance ID: DTXSID00461278
• Nikkaji Number: J1.348.589E
• Mol file: 86734-59-0.mol

Synonyms:86734-59-0;3-benzyloxy-2-hydroxy benzaldehyde;2-hydroxy-3-phenylmethoxybenzaldehyde;3-(BENZYLOXY)-2-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-hydroxy-3-(phenylmethoxy)-;SCHEMBL986050;DTXSID00461278;IDQPYNNNKOORPJ-UHFFFAOYSA-N;3-benzyloxy-2-hydroxy-benzaldehyde;EN300-267729;A1-06983;Z2181947377

Chemical Property of 3-Benzyloxy-2-hydroxy benzaldehyde

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 236

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC(=C2O)C=O

Technology Process of 3-Benzyloxy-2-hydroxy benzaldehyde

There total 11 articles about 3-Benzyloxy-2-hydroxy benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,3-bis(benzyloxy)benzaldehyde (5779-91-9) → 3-benzyloxy-2-hydroxybenzaldehyde (86734-59-0)

Guidance literature:

With magnesium bromide diethyl etherate; In diethyl ether; toluene; at 60 ℃; for 8h; Inert atmosphere;

DOI:10.1002/chem.202003805

Reference yield: 90.0%

3-benzyloxy-2-(3-methyl-but-2-enyloxy)-benzaldehyde → 3-benzyloxy-2-hydroxybenzaldehyde (86734-59-0)

Guidance literature:

With cerium(III) chloride; sodium iodide; In acetonitrile; for 3h; Heating;

DOI:10.1246/cl.2000.738

Reference yield: 85.0%

3-(benzyloxy)-2-methoxybenzaldehyde (273200-57-0) → 3-benzyloxy-2-hydroxybenzaldehyde (86734-59-0)

Guidance literature:

With cerium(III) chloride; sodium iodide; In acetonitrile; for 10h; Heating;

DOI:10.1246/cl.2000.738

upstream raw materials:

2,3-bis(benzyloxy)benzaldehyde

2,3-dihydroxybenzaldehyde

benzyl bromide

benzyl chloride

Downstream raw materials:

2-[3-(benzyloxy)-2-hydroxyphenyl]-1,3-dithiane

2-hydroxymethyl-6-(phenylmethoxy)phenol

(4aR,7R,8R,8aR)-6-(2,4-Bis-benzyloxy-6-benzyloxymethyl-phenyl)-2,2-di-tert-butyl-6-methoxy-8-triisopropylsilanyloxy-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-ol

2-(phenylmethoxy)-6-(phenylmethoxymethyl)-phenol