2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one

Base Information

Chemical Name:2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one
CAS No.:1152032-80-8
Molecular Formula:C₂₂H₁₇F₂NO₂S
Molecular Weight:397.445
Hs Code.:

Synonyms:2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one

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Chemical Property of 2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one

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Technology Process of 2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one

There total 4 articles about 2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1427283-70-2
3-(difluoro(phenylsulfanyl)methyl)-3-methoxyisobenzofuran-1(3H)-one

: 100-46-9
benzylamine

: 1152032-80-8
2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 15h; Reflux;
DOI:10.1039/c3ob27193e

Reference yield: 95.0%

: 2142-01-0
N-benzylphthalimide

: 536975-49-2
phenyl (trimethylsilyl)difluoromethyl sulfide

: 1152032-80-8
2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo802794u

Reference yield:

: 85-44-9
phthalic anhydride

: 1152032-80-8
2-benzyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 6 h / -10 - 20 °C

2: thionyl chloride / 5 h / -78 - 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / toluene / 15 h / Reflux

With thionyl chloride; toluene-4-sulfonic acid; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; toluene;
DOI:10.1039/c3ob27193e