2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine

Base Information

Chemical Name:2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine
CAS No.:1414930-14-5
Molecular Formula:C₅₁H₅₉N₅O₉S
Molecular Weight:918.124
Hs Code.:

Synonyms:2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine

Suppliers and Price of 2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine

There total 5 articles about 2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1414930-13-4
2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-β-D-ribofuranosyl)purine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1414930-14-5
2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine

Guidance literature:: With pyridine; at 20 ℃; for 20h; Cooling with ice;
DOI:10.1016/j.bmcl.2012.08.122

Reference yield:

: 1414930-12-3
2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

: 1414930-14-5
2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: pyridine / 20 h / 20 °C / Cooling with ice

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.08.122

Reference yield:

: 133519-49-0
6-amino-9-{(2R,4S,5R)-4-(tert-butyldimethylsilyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]tetrahydrofuran-2-yl}-2-iodo-9H-purine

: 1414930-14-5
2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-(2-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl)purine

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

2: isopropyl alcohol / 20 °C

3: pyridine / tetrahydrofuran / 27 h / 20 °C / Inert atmosphere; Cooling with ice

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5: pyridine / 20 h / 20 °C / Cooling with ice

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.08.122