2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

Base Information

Chemical Name:2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine
CAS No.:1414930-12-3
Molecular Formula:C₄₂H₆₉N₅O₇SSi₂
Molecular Weight:844.276
Hs Code.:

Synonyms:2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

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Chemical Property of 2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

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Technology Process of 2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

There total 3 articles about 2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 14316-61-1
phenoxyacetic anhydride

: 1414930-11-2
2-(1-methylester-2-octylthioethyl)-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]adenine

: 1414930-12-3
2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 27h; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.bmcl.2012.08.122

Reference yield:

: 133519-49-0
6-amino-9-{(2R,4S,5R)-4-(tert-butyldimethylsilyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]tetrahydrofuran-2-yl}-2-iodo-9H-purine

: 1414930-12-3
2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

2: isopropyl alcohol / 20 °C

3: pyridine / tetrahydrofuran / 27 h / 20 °C / Inert atmosphere; Cooling with ice

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.08.122

Reference yield:

: 1414930-10-1
2-methylacrylate-9-[2’-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]adenine

: 1414930-12-3
2-(1-methylester-2-octylthioethyl)-6-phenoxyacetylamino-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 20 °C

2: pyridine / tetrahydrofuran / 27 h / 20 °C / Inert atmosphere; Cooling with ice

With pyridine; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.08.122