2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile

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Chemical Name:2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile
CAS No.:1189134-87-9
Molecular Formula:C₁₇H₁₃ClF₃N₅
Molecular Weight:379.772
Hs Code.:

Synonyms:2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile

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Chemical Property of 2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile

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Technology Process of 2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile

There total 5 articles about 2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20154-03-4
3-(trifluoromethyl)pyrazole

: 1189140-50-8
2-chloro-4-[4-(hydroxymethyl)-3,5-dimethyl-1H-pyrazol-1-yl]benzonitrile

: 1189134-87-9
2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile

Guidance literature:: With di-tert-butyl-diazodicarboxylate; PS-triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 23h;

Reference yield:

: 154606-56-1
2-chloro-4-(3,5-dimethyl-1H-pyrazol-1-yl)benzonitrile

: 1189134-87-9
2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 23 h / 80 °C

2.1: sodium tetrahydroborate / tetrahydrofuran / 20 °C / Ice cooling

2.2: 0.5 h / 20 °C

3.1: di-tert-butyl-diazodicarboxylate; PS-triphenylphosphine / tetrahydrofuran / 23 h / 20 °C

With sodium tetrahydroborate; di-tert-butyl-diazodicarboxylate; PS-triphenylphosphine; In tetrahydrofuran; 3.1: Mitsunobu reaction;

Reference yield:

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 1189134-87-9
2-chloro-4-(3,5-dimethyl-4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1H-pyrazol-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 1.5 h / 0 °C

2.1: 23 h / 80 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 20 °C / Ice cooling

3.2: 0.5 h / 20 °C

4.1: di-tert-butyl-diazodicarboxylate; PS-triphenylphosphine / tetrahydrofuran / 23 h / 20 °C

With sodium tetrahydroborate; di-tert-butyl-diazodicarboxylate; PS-triphenylphosphine; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;