methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate

Base Information

Chemical Name:methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate
CAS No.:958032-67-2
Molecular Formula:C₂₁H₂₀N₄O₄
Molecular Weight:392.414
Hs Code.:

Synonyms:methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate

Suppliers and Price of methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate

There total 5 articles about methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 958032-65-0
methyl 3-amino-2-(3-methoxypropylamino)benzoate

: 100663-26-1
3-cyanobenzoyl isothiocyanate

: 958032-67-2
methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate

Guidance literature:: methyl 3-amino-2-(3-methoxypropylamino)benzoate; 3-cyanobenzoyl isothiocyanate; In dichloromethane; at 20 ℃; for 0.0833333h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 3970-35-2
2-chloro-3-nitrobezoic acid

: 958032-67-2
methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 12 h / 0 °C / Reflux

2.1: triethylamine / tetrahydrofuran / 12 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h

4.1: dichloromethane / 0.08 h / 20 °C

4.2: 20 °C

With thionyl chloride; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 53553-14-3
2-chloro-3-nitrobenzoic acid methyl ester

: 958032-67-2
methyl 2-(3-cyanobenzamido)-3-(3-methoxypropyl)-3H-benzo[d]imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 12 h / Reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h

3.1: dichloromethane / 0.08 h / 20 °C

3.2: 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;