3970-35-2

Usage

Uses

Used in Chemical Synthesis:
2-Chloro-3-nitrobenzoic acid is used as a reagent in the synthesis of new biprivileged molecular scaffolds of tetracyclic indolo-benzodiazepines and indolo-quinoxalines. It plays a crucial role in the microwave-promoted Ulmann condensation with 2-aminopyridines, facilitating the formation of complex molecular structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloro-3-nitrobenzoic acid is utilized as a key intermediate in the synthesis of various drugs and drug candidates. Its ability to participate in condensation reactions with aminoquinolines makes it a valuable component in the development of novel therapeutic agents.
Used in Research and Development:
2-Chloro-3-nitrobenzoic acid is also employed in research and development settings, where it is used to explore new chemical reactions and investigate the properties of phenylquinolylamines. This contributes to the advancement of knowledge in organic chemistry and the potential discovery of new applications for 2-Chloro-3-nitrobenzoic acid.

InChI:InChI=1/C7H4ClNO4/c8-6-4(7(10)11)2-1-3-5(6)9(12)13/h1-3H,(H,10,11)/p-1

Upstream product

• 34662-24-3 3-nitro-2-chlorobenzonitrile 
• 3970-40-9 2-chloro-3-nitrotoluene 
• 118-91-2 ortho-chlorobenzoic acid 
• 873-32-5 2-Chlorobenzonitrile 
• 95-51-2 o-chloroaniline 
• 606-18-8 3-nitroanthranilic acid 
• 7697-37-2 nitric acid 
• 53663-14-2 anhydro-2-hydroxymercuri-3-nitrobenzoic acid 

Downstream Products

• 116702-59-1 2,2'-Dinitrodiphenylamine-6-carboxylic acid 
• 116702-60-4 3-nitro-2-(3-nitro-anilino)-benzoic acid 
• 192181-48-9 3-nitro-2-phenoxybenzoic acid 
• 2497-91-8 2-chloro-3,5-dinitrobenzoic acid 
• 85-38-1 3-nitrosalicylic acid 
• 606-18-8 3-nitroanthranilic acid 
• 108679-71-6 2-chloro-3-aminobenzoic acid 
• 51689-36-2 dibenzo<1,4>dioxin-1-carboxylic acid 
• 133761-32-7 N-(3',5'-Dimethoxyphenyl)-3-nitroanthranilsaeure 
• 134848-08-1 N-((S)-1-Carbamoyl-ethyl)-2-chloro-3-nitro-benzamide 
• 124341-38-4 2-(methylamino)-3-nitro-benzoic acid 
• 89639-98-5 (2-chloro-3-nitrophenyl)methanol 
• 65517-18-2 2,3-Bis-methylsulfanyl-thiobenzoic acid S-methyl ester 
• 237428-12-5 2-<3-(1-hydroxyethyl)anilino>-3-nitrobenzoic acid 

Relevant academic research and scientific papers

Advanced Real-Time Process Analytics for Multistep Synthesis in Continuous Flow**

In multistep continuous flow chemistry, studying complex reaction mixtures in real time is a significant challenge, but provides an opportunity to enhance reaction understanding and control. We report the integration of four complementary process analytical technology tools (NMR, UV/Vis, IR and UHPLC) in the multistep synthesis of an active pharmaceutical ingredient, mesalazine. This synthetic route exploits flow processing for nitration, high temperature hydrolysis and hydrogenation reactions, as well as three inline separations. Advanced data analysis models were developed (indirect hard modeling, deep learning and partial least squares regression), to quantify the desired products, intermediates and impurities in real time, at multiple points along the synthetic pathway. The capabilities of the system have been demonstrated by operating both steady state and dynamic experiments and represents a significant step forward in data-driven continuous flow synthesis.

Nicotinamide derivatives useful as PDE4 inhibitors

This invention relates to nicotinamide derivatives of general formula (I): in which R1, R2 and R3 have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.

Preparation and NMR analysis of 2,6-heterodifunctional halobenzenes as precursors for substituted biphenyls

Preparation and complete characterization of 16 2,6-disubstituted halobenzenes, including nine new compounds, from two common starting materials is described. Seven of the new compounds contain one or two propylthio groups, which have been introduced in two ways. Direct reaction of arenediazonium salts with 1-propanethiolate gives yields comparable to those obtained in a three-step method through sulfonyl chlorides. The 1H- and 13C NMR chemical shifts of 17 1,2,3-trisubstituted benzenes have been correlated with the predicted values and the observed trends explained using commonly available modeling packages.

Process for the production of nitro derivatives of aromatic compounds

Nitroderivates of aromatic compounds which are difficult to nitrate, can readily be obtained by nitration providing that the aromatic compound is treated with nitric acid or another nitrating agent in the presence of aliphatic or cycloaliphatic hydrocarbons monosubstituted or polysubstituted by halogen, the nitro group or an alkyl sulphonyl group, and the nitro derivative formed subsequently isolated.