5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate

Base Information

Chemical Name:5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate
CAS No.:1407998-49-5
Molecular Formula:C₂₅H₂₃BrN₄O₄S
Molecular Weight:555.452
Hs Code.:

Synonyms:5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate

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Technology Process of 5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate

There total 6 articles about 5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1407998-48-4
5-bromo-8-hydroxy-N-(4-(dimethylamino)benzyl)-1,6-naphthyridine-7-carboxamide

: 98-59-9
p-toluenesulfonyl chloride

: 1407998-49-5
5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate

Guidance literature:: With triethylamine; In chloroform; at 50 ℃; for 5.16667h;
DOI:10.1021/jm300667v

Reference yield:

: 410544-37-5
5-bromo-8-hydroxy-[1,6]naphthyridine-7-carboxylic acid methyl ester

: 1407998-49-5
5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 20 h / Reflux

2: triethylamine / chloroform / 5.17 h / 50 °C

With triethylamine; In chloroform; toluene;
DOI:10.1021/jm300667v

Reference yield:

: 19293-58-4
(4-aminomethylphenyl)dimethylamine

: 1407998-49-5
5-bromo-7-(4-(dimethylamino)benzylcarbamoyl)-1,6-naphthyridin-8-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / Reflux

2: triethylamine / dichloromethane / Inert atmosphere; Reflux

With triethylamine; In dichloromethane; toluene;
DOI:10.1039/c2ob26710a