tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate

Base Information

Chemical Name:tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate
CAS No.:1305311-00-5
Molecular Formula:C₂₃H₃₇N₃O₅
Molecular Weight:435.564
Hs Code.:

Synonyms:tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate

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Technology Process of tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate

There total 3 articles about tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16874-17-2
L-phenylalanine tert-butyl ester

: 331779-00-1
(S)-tert-butyl N-[1-chloro-1-(hydroxyimino)-3-methylbutan-2-yl]carbamate

: 1305311-00-5
tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate

Guidance literature:: With triethylamine; In diethyl ether; at 20 ℃; optical yield given as %de;
DOI:10.1039/c0ob01193b

Reference yield:

: 79069-51-5
(S)-N-tert-butoxycarbonylvalinal

: 1305311-00-5
tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 0.25 h / 80 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 20 °C

3: triethylamine / diethyl ether / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01193b

Reference yield:

: 87694-52-8
tert-butyl (S)-1-(N-methoxy-N-methylcarbamoyl)-2-methylpropylcarbamate

: 1305311-00-5
tert-butyl (S)-2-{[(S)-2-tert-butoxycarbonylamino-N-hydroxy-3-methylbutanimidoyl]amino}-3-phenylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.67 h / -40 °C

2: hydroxylamine hydrochloride; sodium acetate / ethanol / 0.25 h / 80 °C

3: N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 20 °C

4: triethylamine / diethyl ether / 20 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01193b