[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

Base Information

Chemical Name:[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide
CAS No.:130954-02-8
Molecular Formula:Br*C₄₇H₆₁N₃O₆PSi₂
Molecular Weight:931.067
Hs Code.:

[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

Synonyms:[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

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Chemical Property of [(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

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Technology Process of [(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

There total 1 articles about [(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1779-49-3
Methyltriphenylphosphonium bromide

: 119411-03-9
N⁴-benzoyl-1-<3,5-O-(tetraisopropyldidiloxane-1,3-diyl)-β-D-erythro-pentofuran-2-ulosyl>cytosine

: 119411-04-0
N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine

: 130954-02-8
[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1.) hexane, THF, -20 deg C, 1 h, 2.) RT, 2 h;
DOI:10.1021/jm00106a049

Reference yield: 52.0%

: 130954-02-8
[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

: 119411-04-0
N⁴-benzoyl-1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>cytosine

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm00106a049

Reference yield:

: 130954-02-8
[(2R,3S,3aR,9aR)-2-(4-Benzylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

: 130954-03-9
N⁴-benzoyl-2'-deoxy-2'-methylidenecytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / NaH / tetrahydrofuran / 2 h / Ambient temperature

2: 88 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm00106a049